The Use of Rauwolfia serpentina in Hypertensive Patients
نویسندگان
چکیده
The root of Sarpgandha is a species of flowering plant in the family Apocynaceae has been traditionally used in Ayurveda for many years to treat a variety of diseases that at first thought appear to bear little similarity to one another. These include insanity, epilepsy, insomnia, hysteria, eclampsia and hypertension. On reflection, however, these various diseases could have a common denominator if they were all relieved symptomatically by a sedative or a ‘relaxing’ drug such as Rauwolfia. In the fifty decade, its root gained popularity for its effect on hypertension. The alkaloid found in its root is attributed to anti hypertensive pharmacological action. Thus, initially serpine was isolated with an objective of predictable and better efficacy in the management of hypertension. Ayurveda believes in use of whole herb because of apparent benefits over the extract. Thewhole herb has many components which can:(1) Help in biotransformation into pharmacoactive forms(2) Enhance bioavailability (3) Reduce the possible side effects(4) Help in smooth excretion and(5) Prevent development of possible drug resistance.These hypothesis is proved to be true in case of Sarpagandha as Reserpine has reported many ADRs and also human population have developed drug resistance resulting in discontinuation of Reserpine in hypertension management whereas Sarpagandha root is still in wide use.The article will be review the concepts of whole herb and its extracts, published information in this regard in order to draw a possible suggestive conclusion for safe and effective use of sarpagandha .
منابع مشابه
Depressive reactions in hypertensive patients; a comparison of those treated with Rauwolfia and those receiving no specific antihypertensive treatment.
Because of reports that derivatives of Rauwolfia serpentina may cause severe mental depression when used in the treatment of hypertension, the depressive reactions and possible contributing factors were studied in a group of 387 hypertensive patients. Some of the patients received no specific antihypertensive medication; some were treated with Rauwolfia derivatives alone and some with Rauwolfia...
متن کاملRauwolfia serpentina in the treatment of high blood-pressure.
The root of the Rauwolfia serpentina Benth (N. 0. Apocyanaciae) has been in use in India for hundreds of years for a host of unrelated ailments. Since 1949, after the English publication of a clinical report by the author on Rauwolfia serpentina therapy in fifty cases of essential hyperten-sion, the plant has gained universal acclamation as a useful therapeutic weapon in high blood pressure sta...
متن کاملA Comparison of Those Treated with Rauwolfia and Those Receiving No Specific Antihypertensive Treatment
Because of reports that derivatives of Rauwolfia serpentina may cause severe mental depression when used in the treatment of hypertension, the depressive reactions and possible contributing factors were studied in a group of 387 hypertensive patients. Some of the patients received no specific antihypertensive medication; some were treated with Rauwolfia derivatives alone and some with Rauwolfia...
متن کاملRauwolfia serpentina in the treatment of high blood pressure; a review of the literature.
The root of the Rauwolfia serpentina Benth (N. 0. Apocyanaciae) has been in use in India for hundreds of years for a host of unrelated ailments. Since 1949, after the English publication of a clinical report by the author on Rauwolfia serpentina therapy in fifty cases of essential hyperten-sion, the plant has gained universal acclamation as a useful therapeutic weapon in high blood pressure sta...
متن کاملHPTLC method validation of reserpine in Rauwolfia serpentina – A High Value medicinal Plant
Rauwolfia serpentina medicinal value well known in various system of medicine all over the world. Reserpine is an indole alkaloid and is important constituent of Rauwolfia which is reported to posses anti hypertensive and tranquilizing activity. In the present study High Performance Thin Layer Chromatography has been developed for quantification of Reserpine in Rauwolfia and its allied preparat...
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تاریخ انتشار 2016